Nagalase is an extracellular matrix-degrading enzyme that is secreted by cancerous cells in the process of tumor invasion. It is also an intrinsic component of the envelope protein of various virions, such as HIV and the influenza virus.
How is nagalase associated with Autism?
What elevated enzyme do individuals on the spectrum share in common with those battling cancer: Nagalase. Why? My research leads me to believe this enzyme is not able to be fought in our immune-suppressed children. Where does it come from? Speculations I have is that a live virus, or multiple ones find there way into your body to attack the GC proteins in the body. Nagalase is an enzyme that prevents Vitamin D receptors (VDR) from being activated on the surface of the macrophages. As a result, macrophages are not “activated” leaving your immune systems depleted and not being able to properly respond to invaders in your body.
Macrophages are large white blood cells and an integral part of our immune system. Its job is to locate microscopic foreign bodies and ‘eat’ them. Macrophages use the process of phagocytes to engulf particles and then digest them. Nagalase inactivates macrophages (you can watch a video of this here).
Common carriers that produce or contain nagalase (suspected) are the HIV and Influenza virus. Influenza is also commonly referred to as the Flu Shot. Yes, the one now recommended to be safe for pregnant women. Babies, toddlers and children are mandated to receive as part of the CDC schedule in the USA. You get these viruses, or portions of them injected into your body and science tells us that your immune system builds antibodies to defend from a virus like this if it was ever to come in to your body again. This vaccine is supposed to create immunity from the strain of Influenza for that season.
But what else comes with it? I have my suspicions as many other do as well. No matter the carrier it has to be dealt with.
I like to think of nagalase as virus poop, or the bad stuff that is produced in your body by a virus. Elevated nagalase has a detrimental effect on your immune system and opens the door to chronic infections. Nagalase has immune-suppression properties which makes sense why those with cancer or children with ASD have elevated levels. Many children on the spectrum have an array of associated condition that also affect the efficiency of the immune system so nagalase is just added to the list of what needs to be addressed.
Baseline nagalase levels in a human would be < 0.95. A healthy college student with a nagalase level of 0.4 is not uncommon. My son’s at 4 years old was 2.9. Even after a two years vaccine and antibiotic free, Gluten Free, Cassin Free, Soy Free, Sugar Free and organic juice diet. How is this even possible when we do not have exposure to any environmental elements? Again you can go to speculations.
No matter how it has accumulated or where it came from we’ve worked on chelation in a number of ways. Supplements assist, specific amino acids, activated charcoal and bentonite clay added daily to his diet has helped.
The current controversial treatment for nagalase is the use of GcMAF through injections or activated cream applied to the skin around glands. GcMAF (Gc protein macrophage activation factor) is an immune-regulating compound originating in Europe that may have benefit to help with immune system health. It has been used in HIV and cancer for several years. More recently, doctors and researchers have been considering GcMAF for use in patients with illnesses and conditions like autism.
There is a great site called The GcMAF Book that is free online and will walk you through the entire process. This is a must-read for any autism parent that is considering GcMaf creams or injections as a possible treatment.
Let’s get to some science:
The Gc-Protein has a sugar side chain consisting of three sugar molecules , namely N – acetyl galactosamine , galactose, and sialic acid a so-called “tri- saccharide” (= “triple sugar”). When sialic acid and galactose are removed from this tri- saccharide, N -acetyl- galactosamine remains as a single sugar moiety.
For Gc-Protein modified in this manner a strong activating effect on macrophages has been described: this modified Gc-Protein is a “Macrophage-Activating Factor”, abbreviated as “MAF”. More specifically the partially de-glycosylated Gc protein -derived macrophage-activating molecule is called “Gc -MAF” ( Saharuddin et al. 2002 Kuchiike et al. , 2013 Kisker et al. 2003)
It is assumed that this partial sugar elimination (de-glycosylation) from the Gc protein is accomplished under natural conditions by enzymes in immune cells, namely by a so-called “galactosidase” of B-Lymphocytes and a “sialidase” by T-Llymphocytes.
Nagalase inactivates GcMAF?
The enzyme “Nagalase” completely eliminates the sugar side chain of the Gc protein: the thus-modified Gc protein can no longer be converted to Gc MAF, its immune-stimulatory effect is no longer available. In other words, the effect of Nagalase on Gc Protein prevents the formation Gc -MAF. Insofar, tumor-derived Nagalase may have immune-suppressible properties.
- Nagalase is an endogenous enzyme in sugar metabolism
- Tumor cells can produce Nagalase; sources can be a retrovirus, herpes viruses, influenza, intestinal bacteria, HERVs.
- Altered intestinal flora and changes in gut permeability may be a major factor in this entire clinical picture
- Gc MAF is a macrophage-activating factor , which is produced from Gc-Protein
- Nagalase produced by tumors can prevet the formation of Gc-MAF from Gc-Protein.
- Artificially produced Gc-MAF is used as an immune-stimulatory compound
- The amount of detectable serum Nagalase is measured to check whether a Gc-MAF therapy should be considered (therapy indication) and to monitor the effect of Gc-MAF therapy ( “therapy monitoring”)
- Additional laboratory parameters are thought to be of importance for Gc -MAF therapy: Vitamin D and calcium levels in blood, the genetic variants of the vitamin D receptor, and the serum levels of soluble uPA receptor.
If you are interested in starting GcMAF / MafActive cream treatments then I would suggest to do a consultation with Candice Bradstreet. She is the sister-in-law of Dr Jeff Bradstreet and very active and knowledgeable with treatments.